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Medications

Naldemedine oral tablets

What is this medicine?

NALDEMEDINE (nal DEM e deen) is used to treat constipation caused by opioids (pain medicine). Tell your health care professional if you stop taking your opioid pain medicine.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Tell your healthcare provider if you stop taking your pain medicine. If you stop taking your pain medicine, you should also stop taking this medicine. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • new or worsening stomach pain

  • severe or prolonged diarrhea

  • signs and symptoms of opioid withdrawal such as sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • nausea

  • vomiting

What may interact with this medicine?

  • amiodarone

  • aprepitant

  • atazanavir

  • captopril

  • carbamazepine

  • certain medicines for fungal infections like ketoconazole and itraconazole

  • clarithromycin

  • cyclosporine

  • diltiazem

  • erythromycin

  • methylnaltrexone

  • naloxone

  • naltrexone

  • phenytoin

  • quercetin

  • quinidine

  • rifampin

  • ritonavir

  • saquinavir

  • St. John's Wort

  • verapamil

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • cancer or tumor in abdomen, intestine, or stomach

  • diverticulitis

  • history of bowel blockage

  • history of stomach ulcer

  • inflammatory bowel disease

  • kidney disease

  • liver disease

  • Ogilvie's syndrome

  • stomach or intestine problems

  • an unusual or allergic reaction to naldemedine, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor for regular check ups. Tell your doctor if your symptoms do not get better or if they get worse.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2018 Elsevier