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Medications

Lurasidone oral tablet

What is this medicine?

LURASIDONE (loo RAS i done) is an antipsychotic. It is used to treat schizophrenia or bipolar disorder, also known as manic-depression.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 10 years for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • abnormal production of milk

  • anxious

  • breast enlargement in both males and females

  • breathing problems

  • confusion

  • difficulty moving, slow movements, tremor

  • elevated mood, decreased need for sleep, racing thoughts, impulsive behavior

  • fever or chills, sore throat

  • males: trouble getting or maintaining an erection

  • missed or irregular menstrual periods

  • restlessness, pacing, inability to keep still or need to keep moving

  • seizures

  • signs and symptoms of high blood sugar such as dizziness; dry mouth; dry skin; fruity breath; nausea; stomach pain; increased hunger or thirst; increased urination

  • signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired

  • signs and symptoms of neuroleptic malignant syndrome such as confusion; fast or irregular heartbeat; high fever; increased sweating; stiff muscles

  • signs and symptoms of tardive dyskinesia such as uncontrollable head, mouth, neck, arm, or leg movements

  • sudden numbness or weakness of the face, arm or leg

  • suicidal thoughts or other mood changes

  • trouble sleeping

  • trouble swallowing

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • drowsiness

  • nausea

  • runny nose

  • tiredness

  • weight gain

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • avasimibe

  • certain medicines for fungal infections like ketoconazole, voriconazole

  • certain medicines for seizures like carbamazepine, phenytoin

  • clarithromycin

  • mibefradil

  • rifampin

  • ritonavir

  • St. John's Wort

This medicine may also interact with the following medications:

  • atazanavir

  • bosentan

  • certain medicines for anxiety or sleep

  • diltiazem

  • efavirenz

  • erythromycin

  • etravirine

  • fluconazole

  • grapefruit juice

  • medicines for blood pressure

  • modafinil

  • nafcillin

  • verapamil

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • dementia

  • diabetes

  • difficulty swallowing

  • heart disease

  • history of breast cancer

  • kidney disease

  • liver disease

  • low blood counts, like low white cell, platelet, or red cell counts

  • low blood pressure

  • Parkinson's disease

  • seizures

  • suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member

  • an unusual or allergic reaction to lurasidone, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. It may be several weeks before you see the full effects of this medicine. Notify your doctor or health care professional if your symptoms get worse, if you have new symptoms, if you are having an unusual effect from this medicine, or if you feel out of control, very discouraged or think you might harm yourself or others.

Do not suddenly stop taking this medicine. You may need to gradually reduce the dose. Ask your doctor or health care professional for advice.

You may get dizzy or drowsy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase dizziness and drowsiness. Avoid alcoholic drinks.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.

This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2018 Elsevier